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In mice, they found that the development of a "male" brain required the hormone testosterone over a critical period of development.
If they restrained the release of testosterone, they created male mice who were essentially able to ovulate (at least as close as you can get without having ovaries). They found that restraining the release of estrogen did not have the same effect for female mice.
In effect, the brain defaults to female. If any stimuli interrupts the hormonal balance during the development period, permanent changes to the structure of the brain can occur, changes that may imply a female brain in a male body.
Hey, look at that! It only works in development! In other words, you are stuck with the sex that you were born as.