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A .223 diameter bullet is automatically going to be more lethal that a .45 diameter bullet? Um...:lamo
Yes a 223/556 is going to be more lethal then a 45 auto. as long as all other factors, IE shot placement, are the same. That you don't know this says a lot about how little you know.
And because I know you like to play dumb games we are talking about a 556 fired from a rifle and 45 from a pistol as that is what the topic of this thread is about.