It depends.
If I have someone shooting at me from behind a screen of humanity and they won’t stop, and I announce to these people, “Hey, you better get out of the way because I’m tired of being shot at and I’m going to start shooting back. I’m giving you a day to move, but after that I’m shooting through you to get to them if I have to. Just saying.”, they better know that in 24 hours I’m going to start shooting. I won’t want to hurt anyone who wasn’t trying to hurt me, and I’ll try hard and aim carefully, but if it’s the only way I can get to those who are hurting me…
It’s far from perfect, and it will be my last resort, but if everything else has failed at some point I’m protecting myself. There are limits.