Can you articulate a justification for a state seceding from the United States?
Absolutely.
First of all, there is the Constitution itself. The Tenth Amendment reads thus: "The powers not delegated to the United States by the Constitution, nor prohibited by it to the states, are reserved to the states respectively, or to the people."
Given that the Feds are not Constitutionally granted the power to keep the union together by any means necessary, and the States are not Constitutionally denied the right to secede, it stands to reason that they inherently have the right to do so.
If you accept that they inherently have the right to do so, then this part of the argument is over; exercise of a right in a way which does not deny another person or group of people of their Constitutional rights never needs to be justified.
What types of issues/grievances might justify a state withdrawing from the United States?
The House of Representatives, which was intended to proportionally represent the population of the nation at large, now has a fixed membership, the result being that one Representative is now beholden to a larger and larger number of people every day. The options left to a member of the House wishing to keep their position are to either sell out for the campaign dollars needed to canvass their district every 2 years, or spend most of their time grassroots campaigning.
Whichever course is chosen, the fact that the reelection rate in the House is so high serves as proof that one of those options is being chosen so often that the people themselves are not being served.
The Senate, which was intended to answer directly to the governments of the States (which in terms answers much more directly to the people than the Feds do), is now popularly elected. Senators are faced with the same choices that Representatives are face and have more territory to cover -- the only differences are they have a longer term and are responsible for representing even more people.
In short, the people who claim to represent us are physically incapable of hearing more than a fraction of our voices, taking more than a fraction of our phone calls, or reading more than a fraction of our letters, so they can't possibly know what our interests or concerns are. They can't even represent what they believe to be our interests if they want more than one term in office, because their choices are to either do their job or get reelected.
While a genuinely proportional scheme in the House of Representatives would mean a lot more people jockeying to be heard and an exponential rise in inefficiency, efficiency was
never a part of the design -- in fact, a certain amount of inefficiency was built in as a natural hand-brake on the government, since the founders believed (quite correctly) that a government will
always move from less to more power in the long run.
With this in mind, go back and read the Declaration of Independence. WHen you do, keep in mind that this nation was structured, under the Constition, to be a collection of strong state governments held together by a federal government -- answerable
both to the people and state governments -- with a moderate amount of power.
A great many of the grievances which were given voice by that document can be spoken again -- this time against our own federal government.
If that doesn't justify a move for secession, I don't know what does.