He defines something that I think a lot of people get a vague sense of at some point in their life. For me, it was when I was around 3. My uncle was reviewing colors with me, which I had down pretty well at the time. And it suddenly occurred to me. What if he sees blue the way I see red? What if, if I could use his eyes for a minute, the sky looked red and apples looked blue? What would be correct? If I see the apple as red, and someone elses red looks blue to me, what is the apple really? Years later I figured it was impossible to tell and in the end wouldn't really matter anyway. It's pretty cool he never gave up and found a way to apply less fallible science to the problem, on top of defining the problem better than I ever could. It ties in to the brain in the vat / Deus Deceptor /
The Matrix type problems, but in a way you can pit science against it and there's a chance for real answers.
A friend of mine referred me to the
Double Slit Experiment (it's G rated, I swear), and my first reaction was to deny that it was even possible for such an anomaly to happen, never mind be predictably reproducible. The only logical conclusion is that the very act of perceiving reality has an impact on reality somehow. Which would mean that there's a whole lot of stuff we are really clueless about as a species.