Professionally, Lowe is an actor, and a very well known one who, on that basis alone, attracts attention to the productions in which he performs. When Lowe (or any other actor) comports himself as a political satirist, his doing so alters the approbation of him that some of his fan base have, and, importantly, it does so as a result of something that has nothing to do with his acting abilities.
I won't go so far as to say actors should refrain from remarking on politics and political figures; however, I will say that their so commenting has consequences that may manifest themselves, among other ways, negatively with regard to their career as actors. If they're willing to accept and deal with those consequences, they should say whatever they want that augurs to effect them. If, however, actors are unwilling to be held accountable for their remarks, they should either retract their remarks, or, better yet, keep mum in the first place.
Freedom of expression is not freedom from non-governmentally imposed consequences of having expressed oneself. That reality was discovered by MLK, JFK, RFK, Heather Heyer, Harvey Milk, Malcolm X, and a host of others who've been killed or injured as a result of freely expressing themselves. Of course, assassination isn't the the only consequence. Ostracization and rebuke are two more, and they're the consequences actors most likely must face, and those outcomes have the potential to substantively end an actor's career.
So what's acceptable political satire for an actor? Whatever the anticipated fan base/viewers of the actor's performance(s) will bear.