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To nearly the extent that it constitutes the vast majority of the cost differential?
Absolutely impossible.
The US absolutely does have high incidents rates of both, and they do explain _some_ of that differential, but not nearly to the extent it comes anywhere close to accounting for more than a doubling in per capita costs vis a vis other developed countries. For example, obesity and diabetes prevalence in the US are each only about 5% greater as a % of the population than in Australia, and yet its per capita costs are more than double; 113% higher. This is clearly and predominantly a systemic issues rather than the fault of individuals. Sure, the state of general fitness in the country could use substantial improvement, but let's put the majority of the blame where it actually lies, rather than it's just because people are lazy and indolent that the American healthcare is bar the most costly and inefficient in the world. I apologize for the incisive tone, but it legitimately bothers me when people try to imply (or outright state) that the fault is not with the system but the people victimized by it.
Conversely, it bothers me when adult citizens are broadly and generally characterized as victims.