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Just saw your correction. While I am a huge Ruger fan, I own 10 of their products, I would say a .22 LR is not really the best choice for self defence. Great plinking gun and will do if nothing else is available. My Opinion is a 380 Cal is as small as you want to go and almost every manufacturer makes some good ones, Ruger and Glock being two to look at. Good Luck.
I agree- I shoot steel matches 6-8 times a month from May through October. I see lots of people shooting lots of 22 semi autos-My wife shoots a SIG Mosquito-a girl I coach shoots a SW Victory, and I shoot a CZ KADET. While they are very reliable, they all have jammed or failed to fire. So I cannot recommend a 22 self loader for self defense. What I can recommend is a 22 Caliber revolver loaded with really hot 22's like the Stingers. That is a good low recoil viable option and if you get a bad round, you just pull the trigger again. But for most people, a 380 or heavier is a better choice.