Page 1 of 3 123 LastLast
Results 1 to 10 of 21

Thread: New LDL-lowering drug in trials for statin-intolerant patients

  1. #1
    Sage

    JacksinPA's Avatar
    Join Date
    Dec 2017
    Last Seen
    Today @ 04:22 PM
    Gender
    Lean
    Progressive
    Posts
    7,763

    New LDL-lowering drug in trials for statin-intolerant patients

    Trial Explores Use of Bempedoic Acid to Reduce LDL Cholesterol | MD Magazine

    Trial Explores Use of Bempedoic Acid to Reduce LDL Cholesterol

    A trial exploring the effects of bempedoic acid, combined with statin therapy, revealed noticeably decreased levels of low-density lipoprotein cholesterol (LDL-C) without any apparent increase in danger to patients.

    According to the international team of investigators to conduct the study, little is known about the long-term impacts of bempedoic acid as a treatment for elevated cholesterol levels in regard to both safety and efficacy. As such, outcomes for both benefits were assessed in the trial.
    ==============================================
    The normal dosage range for a major statin, Lipitor (atorvastatin) maxes out at 80 mg/day. I once was on 80 mg of it & developed a severe & persistent pain in my upper left arm. This is a disease condition called rhabdomyelysis, which is a serious, degenerative muscle condition. Now I take 60 mg/day of Lipitor + 10 mg/day of Zetia, an older drug. The results have been to lower my total cholesterol to 195 & my LDL to 128, both numbers being in the 'good' range.

    Many patients wuith high LDL have difficulty with high doses of statins due to this painful & dangerous side reaction. A new drug, bempedoic acid, helps block the biosynthesis of cholesterol in the body at a different step in its biosynthesis.

    If it makes it to market, an estimate of its cost would be around $3,500/year.
    “If you don't know where you are going any road can take you there”
    ― Lewis Carroll, Alice in Wonderland

  2. #2
    Sage
    OldFatGuy's Avatar
    Join Date
    Oct 2017
    Last Seen
    03-19-19 @ 12:22 PM
    Gender
    Lean
    Other
    Posts
    6,097

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    Low impact exercise will be just as effective for most patients. Long walks when possible, or multiple short walks, swimming, horseback riding, and so forth, along with a quality diet of fresh greens, reasonable whole fiber carbs, nuts, and avoidance of foods high in trans fats. My total cholesterol rarely exceeds 130, my LDL about 45. I take no statins, and diet controls are less expensive than medications. Two meals per day are sufficient, with light snacking if hungry. Enough carbs to keep the heart happy, but not excessive, an orange or apple if blood sugars dip. Blood sugars are my problem, and keeping them low also assists lower cholesterol levels. It's more of a problem when my blood sugars are too low. I'm a 1/4" shy of 6', I peaked at about 215 18 months ago, now about 185. Weight control is crucial to both cholesterol and sugar levels. I'm 70 and find walking the dog is an immense help for getting me out the door and off my butt. I'd walk the parrot but he isn't interested. My horseback riding days are sadly over. Falling is a potential problem. A few sit ups and push ups in the morning doesn't hurt. If you can't do a few sit ups, you do have a problem.
    What kind of a man is a man who has not left this world a better place?

    No one is in control.

  3. #3
    Sage

    JacksinPA's Avatar
    Join Date
    Dec 2017
    Last Seen
    Today @ 04:22 PM
    Gender
    Lean
    Progressive
    Posts
    7,763

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    People who ancestry stems from the British Isles have a higher than normal number of mutations in the receptor that scavenges HDL & LDL from the blood stream, which results in high cholesterol & atherosclerosis problems. Both of my parents had ancestry in the British Isles. I'm lucky that they finally figured out how to control my LDL.

    I walk 1/2 mile each day with my wife. I also snack only on pistachio nuts.

    Falling is a big problem for anyone over 70. We had an orthopedic bench installed in our bathtub as my balance is not what it was & falls in the tub are a common way older people break their hips, which is usually the gateway accident to dying in a nursing home. I also wear a medic alarm with a fall sensor. It is actually a cell phone, so if I'm conscious I can call them by pressing the big button. If I don't respond, they know where I am so they can direct medical services. They find too many dead older people lying in a puddle of their own urine on the bathroom floor.
    “If you don't know where you are going any road can take you there”
    ― Lewis Carroll, Alice in Wonderland

  4. #4
    Sage
    OldFatGuy's Avatar
    Join Date
    Oct 2017
    Last Seen
    03-19-19 @ 12:22 PM
    Gender
    Lean
    Other
    Posts
    6,097

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    Quote Originally Posted by JacksinPA View Post
    People who ancestry stems from the British Isles have a higher than normal number of mutations in the receptor that scavenges HDL & LDL from the blood stream, which results in high cholesterol & atherosclerosis problems. Both of my parents had ancestry in the British Isles. I'm lucky that they finally figured out how to control my LDL.

    I walk 1/2 mile each day with my wife. I also snack only on pistachio nuts.

    Falling is a big problem for anyone over 70. We had an orthopedic bench installed in our bathtub as my balance is not what it was & falls in the tub are a common way older people break their hips, which is usually the gateway accident to dying in a nursing home. I also wear a medic alarm with a fall sensor. It is actually a cell phone, so if I'm conscious I can call them by pressing the big button. If I don't respond, they know where I am so they can direct medical services. They find too many dead older people lying in a puddle of their own urine on the bathroom floor.
    More people die in bathrooms than in car accidents, but the problem isn't so much falling as too much time on the throne. Blood pressure drops precipitously and the individual can't rise, eventually feinting.

    Not everyone over 70 has issues of balance or bone brittling. Those who spent their lives doing manual labor and exercise regimens suffer from both these problems far less than those who lived more sedentary lives. Lifestyle makes a difference. Before I turned 40, I worked out at least 4 hours per day, vigorously. Then, after a blood test during a routine exam, my blood sugar had spiked leading to a diagnoses of Type I diabetes. I had subconsciously been attempting to control my blood sugar levels with exercise. A year later I suffered a serious heart attack attributed to the diabetes tho it was triggered by getting kicked in the chest by a horse. I had to scale back my exercise regimen, but still maintained at least two hours of vigorous exercise, starting my day with 50 sit ups and 50 push ups, walking 5 miles daily instead of running 10, and reducing weight training by 60%, lighter weights, more repetitions. My doctors firmly believe my exercise regimen has kept me relatively healthy for my age even tho I have progressive congestive heart disease, and survived 5 different types of cancer, including two skin cancers that required serious surgery. Next Wednesday I'm receiving a new pacemaker/defrib device to better assist my heart which now has a failing ventricular chamber in addition to atrial issues. This means when a toilet seat falls from the sky, hits me in the head and I die, my heart will keep beating. This also means no more wild sex on the trampoline. I'm going to miss the trampoline.

    My legs are problematic, but I still average 5 miles of walking daily, with exception of days that are icy. Also, when it rains, the dog refuses to spend time outdoors, so my time walking is curtailed for rain or snow. He's terrified of getting wet. When he stinks, bathing him is an ordeal. 120 lbs of wet dog desperate to escape the tub is a nightmare, even tho he thoroughly enjoys getting toweled down afterwards. He's a wuss of a dog. My wife leaves our home when I announce he's about to get bathed. I don't blame her.

    Since I'm rarely alone, if ever, I don't have need of alert devices. I truly cherish a bit of solitude now and then. Unfortunately, mostly then.
    What kind of a man is a man who has not left this world a better place?

    No one is in control.

  5. #5
    Sensational

    joko104's Avatar
    Join Date
    Jan 2009
    Location
    Paradise
    Last Seen
    @
    Lean
    Undisclosed
    Posts
    38,156
    Blog Entries
    2

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    I'll research bempedoic acid and if it seems beneficial and safe to try I'll buy some. It's pricey, but not outrageously so.
    Bempedoic acid | CAS#738606-46-7 | regulator of lipid and carbohydrate metabolism | MedKoo

  6. #6
    Sensational

    joko104's Avatar
    Join Date
    Jan 2009
    Location
    Paradise
    Last Seen
    @
    Lean
    Undisclosed
    Posts
    38,156
    Blog Entries
    2

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    Quote Originally Posted by OldFatGuy View Post
    More people die in bathrooms than in car accidents, but the problem isn't so much falling as too much time on the throne. Blood pressure drops precipitously and the individual can't rise, eventually feinting.

    Not everyone over 70 has issues of balance or bone brittling. Those who spent their lives doing manual labor and exercise regimens suffer from both these problems far less than those who lived more sedentary lives. Lifestyle makes a difference. Before I turned 40, I worked out at least 4 hours per day, vigorously. Then, after a blood test during a routine exam, my blood sugar had spiked leading to a diagnoses of Type I diabetes. I had subconsciously been attempting to control my blood sugar levels with exercise. A year later I suffered a serious heart attack attributed to the diabetes tho it was triggered by getting kicked in the chest by a horse. I had to scale back my exercise regimen, but still maintained at least two hours of vigorous exercise, starting my day with 50 sit ups and 50 push ups, walking 5 miles daily instead of running 10, and reducing weight training by 60%, lighter weights, more repetitions. My doctors firmly believe my exercise regimen has kept me relatively healthy for my age even tho I have progressive congestive heart disease, and survived 5 different types of cancer, including two skin cancers that required serious surgery. Next Wednesday I'm receiving a new pacemaker/defrib device to better assist my heart which now has a failing ventricular chamber in addition to atrial issues. This means when a toilet seat falls from the sky, hits me in the head and I die, my heart will keep beating. This also means no more wild sex on the trampoline. I'm going to miss the trampoline.

    My legs are problematic, but I still average 5 miles of walking daily, with exception of days that are icy. Also, when it rains, the dog refuses to spend time outdoors, so my time walking is curtailed for rain or snow. He's terrified of getting wet. When he stinks, bathing him is an ordeal. 120 lbs of wet dog desperate to escape the tub is a nightmare, even tho he thoroughly enjoys getting toweled down afterwards. He's a wuss of a dog. My wife leaves our home when I announce he's about to get bathed. I don't blame her.

    Since I'm rarely alone, if ever, I don't have need of alert devices. I truly cherish a bit of solitude now and then. Unfortunately, mostly then.
    Keep going as long as you can. Like an elephant, if a person lies down to die they die. Always keep going, never give up, never stop.

  7. #7
    Sensational

    joko104's Avatar
    Join Date
    Jan 2009
    Location
    Paradise
    Last Seen
    @
    Lean
    Undisclosed
    Posts
    38,156
    Blog Entries
    2

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    A lot of people die in bathrooms. For example, a bowel movement puts a strain on a person's heart, so a lot of heart attacks happen in bathrooms. Drowning in bathtubs due some medical trauma also is not rare.

  8. #8
    Don't Give a Rat's Ass
    SMTA's Avatar
    Join Date
    Sep 2012
    Location
    OH
    Last Seen
    Today @ 04:00 PM
    Gender
    Lean
    Independent
    Posts
    27,546

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    Quote Originally Posted by OldFatGuy View Post
    More people die in bathrooms than in car accidents, but the problem isn't so much falling as too much time on the throne. Blood pressure drops precipitously and the individual can't rise, eventually feinting.

    Not everyone over 70 has issues of balance or bone brittling. Those who spent their lives doing manual labor and exercise regimens suffer from both these problems far less than those who lived more sedentary lives. Lifestyle makes a difference. Before I turned 40, I worked out at least 4 hours per day, vigorously. Then, after a blood test during a routine exam, my blood sugar had spiked leading to a diagnoses of Type I diabetes. I had subconsciously been attempting to control my blood sugar levels with exercise. A year later I suffered a serious heart attack attributed to the diabetes tho it was triggered by getting kicked in the chest by a horse. I had to scale back my exercise regimen, but still maintained at least two hours of vigorous exercise, starting my day with 50 sit ups and 50 push ups, walking 5 miles daily instead of running 10, and reducing weight training by 60%, lighter weights, more repetitions. My doctors firmly believe my exercise regimen has kept me relatively healthy for my age even tho I have progressive congestive heart disease, and survived 5 different types of cancer, including two skin cancers that required serious surgery. Next Wednesday I'm receiving a new pacemaker/defrib device to better assist my heart which now has a failing ventricular chamber in addition to atrial issues. This means when a toilet seat falls from the sky, hits me in the head and I die, my heart will keep beating. This also means no more wild sex on the trampoline. I'm going to miss the trampoline.

    My legs are problematic, but I still average 5 miles of walking daily, with exception of days that are icy. Also, when it rains, the dog refuses to spend time outdoors, so my time walking is curtailed for rain or snow. He's terrified of getting wet. When he stinks, bathing him is an ordeal. 120 lbs of wet dog desperate to escape the tub is a nightmare, even tho he thoroughly enjoys getting toweled down afterwards. He's a wuss of a dog. My wife leaves our home when I announce he's about to get bathed. I don't blame her.

    Since I'm rarely alone, if ever, I don't have need of alert devices. I truly cherish a bit of solitude now and then. Unfortunately, mostly then.
    Completely false.
    10,000 people in the US die each year in toilet related injuries.
    1.3 million people each year die in the US in car accidents.
    Get your facts straight before posting.
    Stop posting garbage.
    Greatness lies not in being strong, but in the right use of strength - Henry Ward Beecher
    Baby sister, I was born game and I intend to go out that way - Rooster Cogburn
    Ted Cassidy's character is a pussy.

  9. #9
    Don't Give a Rat's Ass
    SMTA's Avatar
    Join Date
    Sep 2012
    Location
    OH
    Last Seen
    Today @ 04:00 PM
    Gender
    Lean
    Independent
    Posts
    27,546

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    Quote Originally Posted by joko104 View Post
    A lot of people die in bathrooms. For example, a bowel movement puts a strain on a person's heart, so a lot of heart attacks happen in bathrooms. Drowning in bathtubs due some medical trauma also is not rare.
    Of course you are an expert on human ****.
    Is this hands on experience, or are you just reading voraciously?
    Greatness lies not in being strong, but in the right use of strength - Henry Ward Beecher
    Baby sister, I was born game and I intend to go out that way - Rooster Cogburn
    Ted Cassidy's character is a pussy.

  10. #10
    Don't Give a Rat's Ass
    SMTA's Avatar
    Join Date
    Sep 2012
    Location
    OH
    Last Seen
    Today @ 04:00 PM
    Gender
    Lean
    Independent
    Posts
    27,546

    Re: New LDL-lowering drug in trials for statin-intolerant patients

    Quote Originally Posted by joko104 View Post
    Keep going as long as you can. Like an elephant, if a person lies down to die they die. Always keep going, never give up, never stop.
    Humans are not elephants, and have no biological similarities.
    Are you a certified veterinarian and a human doctor?
    How do you find the time?
    Greatness lies not in being strong, but in the right use of strength - Henry Ward Beecher
    Baby sister, I was born game and I intend to go out that way - Rooster Cogburn
    Ted Cassidy's character is a pussy.

Page 1 of 3 123 LastLast

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •