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Low levels of simple chemical associated with aging, DNA damage

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Surrealistik

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Ars Technica - Roheeni Saxena said:
Approximately ten thousand times each day, the DNA in our cells receives some damage, but most of that damage is repaired by our cells' built-in DNA repair systems. The efficiency of these DNA repair systems decline with age, however, and that's thought to lead to age-related health problems and cancer.

A recent paper published in Science shows that a chemical used in the DNA repair process, nicotinamide adenine dinucleotide (NAD+), has a concentration that declines with age. This decline may drive the age-associated accumulation of DNA damage—a finding that suggests supplementing NAD+ might offset some of the effects of aging.
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Promising, but we'll see what comes of it; more studies and research are definitely needed given the minute scope of the investigation. Even if it proves no fountain of youth in the end, NAD+ supplements could certainly prove to have valuable therapeutic and health promoting uses.

https://arstechnica.com/science/2017...ng-dna-damage
 
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Apologies guys, I thought I included it; should have checked the post afterwords; clipboard buffer was apparently overwritten so no copypasta. :\
 
Surrealistik said:
Promising, but we'll see what comes of it; more studies and research are definitely needed given the minute scope of the investigation. Even if it proves no fountain of youth in the end, NAD+ supplements could certainly prove to have valuable therapeutic and health promoting uses.
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I wouldn't get too excited.

Three to five mice in each arm?

It also brings to mind the extensive benefits of antioxidants....which, in at least some cases, actually end up promoting cancer growth by sucking up all the free radicals that inhibit cancer cell replication....
 
Surrealistik said:
Promising, but we'll see what comes of it; more studies and research are definitely needed given the minute scope of the investigation. Even if it proves no fountain of youth in the end, NAD+ supplements could certainly prove to have valuable therapeutic and health promoting uses.
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I'll believe it when I see bottles of it on TV - "Wait! Order now, and we'll double your order at no extra charge, except for shipping!"
 
Threegoofs said:
I wouldn't get too excited.

Three to five mice in each arm?

It also brings to mind the extensive benefits of antioxidants....which, in at least some cases, actually end up promoting cancer growth by sucking up all the free radicals that inhibit cancer cell replication....
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I'm not. As I stated, it definitely requires additional investigation; the research thus far is scant.
 
Surrealistik said:
Promising, but we'll see what comes of it; more studies and research are definitely needed given the minute scope of the investigation. Even if it proves no fountain of youth in the end, NAD+ supplements could certainly prove to have valuable therapeutic and health promoting uses.
Click to expand...

It'll be interesting to see what comes of this, but it'll be a while before anyone really understands aging. So while this sounds nice, it's doubtful that this is going to immediately lead to humans being able to live unnaturally long lives. The science of even the simplest things is generally 1,000x harder than anyone might think, so whatever pharmaceutical might come from this, it's both unclear and a long way off. It's virtually guaranteed that you cannot just take a NAD+ pill every morning and then simply live until you're 210 without major issues. Even so, it is interesting stuff.
 
chuckiechan said:
I'll believe it when I see bottles of it on TV - "Wait! Order now, and we'll double your order at no extra charge, except for shipping!"
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Such products are available from at least one source. I have seen such products advertised at Life Extension Foundation. I've never taken it though.
 
FieldTheorist said:
It'll be interesting to see what comes of this, but it'll be a while before anyone really understands aging. So while this sounds nice, it's doubtful that this is going to immediately lead to humans being able to live unnaturally long lives. The science of even the simplest things is generally 1,000x harder than anyone might think, so whatever pharmaceutical might come from this, it's both unclear and a long way off. It's virtually guaranteed that you cannot just take a NAD+ pill every morning and then simply live until you're 210 without major issues. Even so, it is interesting stuff.
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You can't take NAD+ pills. Not stable.

However, it does look like you can take an NAD precursor which should work.

http://www.nature.com/articles/ncomms12948
 
Thoreau72 said:
Such products are available from at least one source. I have seen such products advertised at Life Extension Foundation. I've never taken it though.
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Always followed by these statements not evaluated by the FDA.
 
FieldTheorist said:
It'll be interesting to see what comes of this, but it'll be a while before anyone really understands aging. So while this sounds nice, it's doubtful that this is going to immediately lead to humans being able to live unnaturally long lives. The science of even the simplest things is generally 1,000x harder than anyone might think, so whatever pharmaceutical might come from this, it's both unclear and a long way off. It's virtually guaranteed that you cannot just take a NAD+ pill every morning and then simply live until you're 210 without major issues. Even so, it is interesting stuff.
Click to expand...

Trust me, I'm not getting breathless about this until the gold standard double blind human trials are done, but I do think it's a promising start for further investigation.
 
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