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FDA committee recommends first CBD product

WCH said:
Trying to ask me out?
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No but I thought Gunnery Sgt Hartman's comments about Texans was pretty funny. I think the same lines were used in an Officer & a Gentleman.
 
NonoBadDog said:
We get them over the counter.
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Topicals I believe are hemp derived and allowed.

This may be the first salvo of going after medical applications from dispensaries.

The owner of that drug does NOT want you to be able to acquire functionally the same drug at your local dispensary.

Which it is, now.
 
WCH said:
Is it taxed the same as THC product?
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I actually don't know. Particularly the stuff not for human consumption, it may be different.
 
JacksinPA said:
https://en.wikipedia.org/wiki/Cannabidiol

Overview Information
Cannabidiol is a chemical in the Cannabis sativa plant, also known as marijuana. Over 80 chemicals, known as cannabinoids, have been identified in the Cannabis sativa plant. While delta-9-tetrahydrocannabinol (THC) is the major active ingredient, cannabidiol makes up about 40% of cannabis extracts and has been studied for many different uses. According to the U.S. Food and Drug Administration (FDA), because cannabidiol has been studied as a new drug, products containing cannabidiol are not defined as dietary supplements. But there are still products labeled as dietary supplements on the market that contain cannabidiol.

People take cannabidiol by mouth for anxiety, bipolar disorder, a muscle disorder called dystonia, epilepsy, multiple sclerosis, Parkinson’s disease, and schizophrenia.

People inhale cannabidiol to help quit smoking.

A prescription-only nasal spray (Sativex, GW Pharmaceuticals) containing both THC and cannabidiol is used for pain and muscle-tightness in people with multiple sclerosis in over 25 countries outside of the United States.

How does it work?
Cannabidiol has antipsychotic effects. The exact cause for these effects is not clear. But cannabidiol seems to prevent the breakdown of a chemical in the brain that affects pain, mood, and mental function. Preventing the breakdown of this chemical and increasing its levels in the blood seems to reduce psychotic symptoms associated with conditions such as schizophrenia. Cannabidiol might also block some of the psychoactive effects of delta-9-tetrahydrocannabinol (THC). Also, cannabidiol seems to reduce pain and anxiety.
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CBD can be successfully extracted at relatively low cost regardless of the amount of THC present. However, there are a number of marijuana strains, primarily Indica, though Sativa strains work just fine, that have no THC and a high amount of CBD. What allows the effect of CBD to occur is that the cannabinoid that contains the cannabidiol is the “vehicle” that carries the CBD through the blood-brain barrier (BBB) into the CNS, the permeability of which is highly selective, which is why most therapeutic drugs can’t get through the BBB, but the cannabinoid can. That is a rarity.

Anecdotally, I knew of a patient, personally, who was pretty much hospital bound and was taking both opioids and government administered THC. The THC just gets you “high” to take your mind of the pain, but he hated the effect. However, he had marijuana with high cannabidiol content smuggled in and would sneak outside to smoke some when he could. He was thus able to relieve pain enough to cut down his opioid intake by as much as half.

Depending on what state you’re in, you can get bottled CBD that comes with a dropper mailed to you rather easily. Just Google “liquid cannabidiol.” Helps with pain, anxiety and insomnia. But, everybody’s brain chemistry is different.
 
bluesmoke said:
CBD can be successfully extracted at relatively low cost regardless of the amount of THC present. However, there are a number of marijuana strains, primarily Indica, though Sativa strains work just fine, that have no THC and a high amount of CBD. What allows the effect of CBD to occur is that the cannabinoid that contains the cannabidiol is the “vehicle” that carries the CBD through the blood-brain barrier (BBB) into the CNS, the permeability of which is highly selective, which is why most therapeutic drugs can’t get through the BBB, but the cannabinoid can. That is a rarity.

Anecdotally, I knew of a patient, personally, who was pretty much hospital bound and was taking both opioids and government administered THC. The THC just gets you “high” to take your mind of the pain, but he hated the effect. However, he had marijuana with high cannabidiol content smuggled in and would sneak outside to smoke some when he could. He was thus able to relieve pain enough to cut down his opioid intake by as much as half.

Depending on what state you’re in, you can get bottled CBD that comes with a dropper mailed to you rather easily. Just Google “liquid cannabidiol.” Helps with pain, anxiety and insomnia. But, everybody’s brain chemistry is different.
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You sound like you might know something, if you please what do you know about CBD/THC effect on blood sugar?

I currently grind 15-20% AC/DC into an high (25%ish) THC indica, and often top the load with a bit of kief.

THANKS TO THE GODS I LIVE IN WASHINGTON STATE!

tyvm
 
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Ikari said:
I actually don't know. Particularly the stuff not for human consumption, it may be different.
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CBD & THC are 2 different molecules with different biological activities. CDB is used as a medicine to treat certain diseases. THC is a psychoactive drug used for recreation. They are both derived from the same plant, Cannabs sativa.
 
JacksinPA said:
https://www.nbcnews.com/health/health-news/fda-committee-recommends-first-cbd-oil-product-n867511

Cannabidiol - CBD for shorrt — is a cannabis derivative and the approval would be limited to treating seizures caused by Lennox-Gastaut syndrome (LGS) and Dravet syndrome in patients aged 2 and older.

“Epidiolex represents hope for the many individuals living with intractable seizures and rare epilepsies, who every day face incredible challenges and disabling seizures, and live with the continual risk of serious injury and death,” said Philip Gattone, president and CEO of the Epilepsy Foundation.
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Though derived from the marijuana plant (Cannabis sativa), the purified CBD contains none of the psychoactive tetrahydrocannabinol (THC) associated with using the plant in various forms to get 'stoned.' See https://en.wikipedia.org/wiki/Cannabis_(drug)

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It's a good thing. I've been using the salve on my arthritic feet for about 6 months now, and it's awesome. The sublingual drops don't do much for me, but the salve is wonderful.
 
WillyPete said:
In weed-wild California, and presumably in other area where recreational use is legal, they sell plenty of CBD-only products already. Pricing is comparable, though apparently the effective dosage for CBD is considerably lower than THC.

I've seen it packaged as topical creams and edibles (liquid and gummies.)
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Yup and for pets too. Not that crazy expensive. Not cheap either.
 
JacksinPA said:
I don't think it has any recreational use other than hype.
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Why would it have recreational use? It doesnt have any psycho-active properties.
 
Hawkeye10 said:
You sound like you might know something, if you please what do you know about CBD/THC effect on blood sugar?

I currently grind 15-20% AC/DC into an high (25%ish) THC indica, and often top the load with a bit of kief.

THANKS TO THE GODS I LIVE IN WASHINGTON STATE!

tyvm
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Most importantly, I’m not a physician and MJ have different effect on different people as we all have different brain chemistry. That said, in Type 1 diabetes, the immune system attacks the pancreas and prevents it from producing the insulin necessary to move sugar out of the blood and into cells. However, it takes a lot of THC to make that happen (150mg/kg of THC would be about 2 ounces of 25% THC MJ for someone weighing 200 lbs.), but mice studies show CBD works more efficiently. This is the great thing about the cannabinoid as a delivery vehicle. Nothing in our system feels any need to attack the cannabinoid. Therefore, whatever is contained in the cannabinoid can be successfully delivered without other means, such as injection, including injecting therapeutics into the brain. Theoretically, if we could put therapeutic drugs into cannabinoids, the drug could, theoretically, be safely delivered without being rejected by our immune system. Of course, CBD does help with the neuropathic leg and foot pain of people with diabetes.

AC/DC is a Cannatonic phenotype, so I don’t know how you’re getting 25% THC when it shouldn’t be more than 6% with a 20:1 CBD:THC ratio from, perhaps, a 50-50 Sativa-Indica plant. But, unless you have consistently used the same plant from the same grower, and have a high level of confidence of your source’s knowledge of the grow, what said strains really are can vary quite a bit.

BTW, the only other plant in the same family as MJ is the hop plant. If you've ever smelled the aroma of a super-high hop content of beer, you get a seemingly faint MJ aroma.
 
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