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Malaria is resurging with a vengeance on our doorstep but the new drug tafenoquine offers hope

JacksinPA

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Malaria is resurging with a vengeance on our doorstep but the new drug tafenoquine offers hope - ABC News (Australian Broadcasting Corporation)

However, just 150 kilometres north of Australia a more familiar epidemic is unfolding. An ancient parasite is spreading faster than at any time this century.

In Papua New Guinea, malaria is resurging with a vengeance. There were an estimated 1.4 million malaria cases in the country in 2016, which amounts to a 400 per cent increase, according to the World Health Organisation; 3000 people died.

Close to 60 per cent of malaria cases in PNG are among children under 15 years and too many don't survive the onslaught.
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Promising new anti-malarial drugs are in late stage development. The market could be huge as multi-drug-resistant malaria is at nearly epidemic levels in SE Asia.
 
tafenoquine causes serious long-term psychiatric and physical side effects (hallucinations, schizophrenia, self-harm and seizures)

The US and Australia used soldiers as guinea pigs
Federal government backs inquiry into malaria drugs tested on soldiers
https://www.9news.com.au/national/2018/06/07/10/03/controversial-anti-malaria-drugs-inquiry-receives-backing-of-federal-government


From 1998 to 2002, members of the Australian Defence Force were used as trial subjects for mefloquine and tafenoquine.

“We need Defence to be really careful with this stuff in the future,” said Kelly. “We're talking about people here, not guinea pigs, and I think we're united across the aisles here on wanting to see something happen urgently in this space.

Mefloquine, under the brand name Lariam, was ordered for tens of thousands of American service members deployed to malaria-prone parts of the world from the 1980s until 2013, when the United States Food and Drug Administration issued a black box warning.

That’s the FDA’s strictest measure, put on prescription drug labels when there’s evidence of a serious side effect. The drug is now used as a last resort, according to Pentagon officials, reserved for service members who cannot take one of the alternative antimalarials.

From 1998 to 2002, members of the Australian Defence Force were used as trial subjects for mefloquine and tafenoquine.
https://www.wusa9.com/article/news/investigations/australian-mp-calls-for-inquiry-into-antimalarial-drugs-after-wusa9-reports/65-557829777

I travelled to Africa a couple of years ago with my kids and we took Malarone, we became extremely ill, I could not give it to them, it would have killed them if I did, fortunately the area where we went were recently sprayed with DDT... and how sad is it that using DDT is fortunate.

The Australians have developed a vaccine that passed human trial last year, PlasProtecT which also provide cross species protection for the different strains of Malaria

PlasProtecT® consisting of whole malaria parasites that are grown in the laboratory under strictly controlled conditions. These parasites are then treated so they can no longer replicate or cause infection. When these treated parasites are administered as a vaccine, an immune response is raised without causing disease. The immune system is then primed to fight malaria parasites that may enter the body in the future, preventing malaria.

Researchers from Griffith University and the Gold Coast University Hospital have now developed the vaccine to “whole blood stage”. PlasProtecT® uses whole malaria parasites, so it overcomes the limitations of sub unit vaccine approaches and have already shown broad spectrum protection in animal studies. One of the researchers – Griffith University’s Professor Michael Good – is so convinced it is safe he has become the first person to inoculate himself with the trial vaccine. This means they have shown the vaccine is safe for humans to take and for human tests to go ahead.

A pilot clinical study in healthy human volunteers demonstrated the PlasProtecT® approach is safe and able to induce an immune response.
https://malariavaccineproject.com/about/
 
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