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Well, the Russians found out all anyone needed to know about living in zero gravity years before the ISS.
And we now know one thing clearly - human beings are not designed to live in zero gravity for long periods of time. All kinds of physical problems can result when humans are weightless for months/years.
If they go to Mars to live, I think they have got to find a way to make structures with artificial gravity when they get there.
Mars has gravity like any other celestial object.