probable not in the current environment
Things in the US are no where near bad enough to cause a widespread rebellion that would have enough support to overthrow the US government.
What would be required is a massive increase in poverty, increases in social unrests (ie riots), most likely an increase in ethnic/religous tensions.
The poverty would be required to cause the social unrest, and riots which would cause a government crackdown.
The ethnic/religous tensions would provide another motivator for overthrowing the government. Ie the US government is under the control of the "insert ethnic/religous group" and it needs to stop.
The most likely candidates for starting a rebellion in the US in my opinion would be among the white "nationalists" that predominate in the western and south east US. They would also benifit from having a fairly large number of potential recruits who were in the US military and most likely would have ties to people in the US military
But for it to actually happen, is quite remote and things would have to get much much worse economically in the US first