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I guess it depends on your definition of "changed their lives for the better".
Most of my drug-using friends are old burned-out hippies who just want to get through the day so they can get high. Not that there's anything wrong with that- it just hasn't improved their lives that I see or hear evidence of.
Then I would wager that they merely had a sensory experience, rather than one on the symbolic, integral, or recollective-analytical levels.