I probably wouldn't vote for him anyway, but, specifically to address this question, NO the lack of a degree doesn't mean squat to me.
In my work, some of the brightest and most capable people I work with have no degrees at all, and some of the biggest idiots have them. I think college, for the most part, is vastly overrated, and young people generally would be better off getting work right out of high school.
Much better than a college degree, I find, are employees with a military background.
I would be much more inclined to question whether a would-be president is truly qualified to do the job without any sort of military pedigree (Hilary Clinton, for example).