Maybe you should check out what treaties we are a party toReally?
All Debts contracted and Engagements entered into, before the Adoption of this Constitution, shall be as valid against the United States under this Constitution, as under the Confederation.
This Constitution, and the Laws of the United States which shall be made in Pursuance thereof; and all Treaties made, or which shall be made, under the Authority of the United States, shall be the supreme Law of the Land; and the Judges in every State shall be bound thereby, any Thing in the Constitution or Laws of any State to the Contrary notwithstanding.
The Senators and Representatives before mentioned, and the Members of the several State Legislatures, and all executive and judicial Officers, both of the United States and of the several States, shall be bound by Oath or Affirmation, to support this Constitution; but no religious Test shall ever be required as a Qualification to any Office or public Trust under the United States.
I don't see it. Where is there any support in this text for the federal government to regulate “controlled substances”?
Keep in mind that when there was a movement to ban alcohol at the national level, it was widely and correctly understood that the Constitution did not allow it, and that the only legitimate way to do so was to specifically amend the Constitution in order to establish this power, hence, the Eighteenth Amendment.