But---one doesn't need to be a very bright person to know what is adequate to bring down or stop a human being. A "raging beast" on certain narcotics can be hit dozens of times and still not die. A strong person on an adrenaline high can be shot through the heart and still fight on for 10 seconds.
I can simply rely on the thinking of every single modern police force and military on the earth. None use .22 long rifles or similar weak rounds as their standard issue carry weapons.
Sorry, but size does matter.