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Are LSD and Psilocybin addictive?

Are LSD and Psilocybin addictive?

  • Total voters
    36
sbrettt said:
Oh okay, you're talking an indirect activation?
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the activation itself is direct.

Together, these results are consistent with a direct interaction between LSD and a portion of dopamine D2/3 receptors in pig brain, possibly contributing to the psychopharmacology of LSD.
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Interaction between LSD and dopamine D2/3 binding si... [Synapse. 2005] - PubMed - NCBI

These results suggest that LSD not only interacts with dopaminergic receptors but also has a unique capacity for modulating dopaminergic transmission.
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Lysergic acid diethylamide (LSD) is a partial agoni... [Life Sci. 1998] - PubMed - NCBI

I am not an expert on addiction here, but that is just the first couple of hits from a quick google scholar search. I think that once the drug wears off it is no longer bound to the seratonin receptors so they again function normally, and any releases of seratonin while under the influence are not a drastic departure from normal to begin with.
 
marduc said:
the activation itself is direct.



Interaction between LSD and dopamine D2/3 binding si... [Synapse. 2005] - PubMed - NCBI



Lysergic acid diethylamide (LSD) is a partial agoni... [Life Sci. 1998] - PubMed - NCBI

I am not an expert on addiction here, but that is just the first couple of hits from a quick google scholar search. I think that once the drug wears off it is no longer bound to the seratonin receptors so they again function normally, and any releases of seratonin while under the influence are not a drastic departure from normal to begin with.
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LOL with my lack of knowledge those links might as well look like this; "fjkbvjkrtbgukbtrkgvktrgbvtyrb". Although it sounds like it doesn't bind to dopamine like cocaine, but it promotes the release of it? Is this only for LSD, or does it also apply to Psilocybin?
 
Here is a great link I just stumbled on..grab the LSD mouse and plop him in the chair and enjoy :)

Mouse party!
 
Hard Truth said:
From both my reading and personal experiences, most people do not desire to use those drugs on a regular basis, even after using them several times, so they are not addictive. I did know on guy who used LSD everyday for a few months, but he had existing mental issues and seemed to be wanting to avoid doing anything with his life.

There is a theory that people who use XTC and other psychedelics often for a long time tend to get into speed abuse later on, because they no longer get the same effect from the psychedelics. (they don't get the same effects from the speed as they did with XTC, but it does provide a consistent high)
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I've been known to get some pretty incredible highs from xtc.

This one gives me eargasms every time:

 
sbrettt said:
Actually, where I come from XTC's are a street name for fake Ecstasy. I'm thinking you were referring to real Ecstasy. I don't think it's accurate to lump MDMA with Psilocybin/LSD when talking about addiction. Yes, they both have hallucinogenic properties, but LSD and Psilocybin do not interact with the reward center. MDMA on the other hand, heavily interacts with the reward center.
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Ex and MDA are derivatives of speed (methedrine) so they can be addictive. Speed was dangerously seductive for me. Cocaine is one of the most sinister addictions. I smoked crack back when you made it yourself and called it 'freebase'. Went through a paycheque in a weekend and said, "Well, we on't be affording this particular hobby." I know two guys who are alcohol addicts who've stayed dry for years by smoking copious amounts of pot.
I guess what I'm getting at is that addiction is a complicated subject. Someone said only opiates and nicotine are addictive, but I disagree. Someone else (Maggie?) said maybe anything that makes you feel good can be addictive- I think that's closer to the truth.
It might have more to do with the addict than the substance. I suspect that for some addicts, if the substance they're addicted to didn't exist they'd be addicted to something else.
 
Grand Mal said:
Ex and MDA are derivatives of speed (methedrine) so they can be addictive. Speed was dangerously seductive for me. Cocaine is one of the most sinister addictions. I smoked crack back when you made it yourself and called it 'freebase'. Went through a paycheque in a weekend and said, "Well, we on't be affording this particular hobby." I know two guys who are alcohol addicts who've stayed dry for years by smoking copious amounts of pot.
I guess what I'm getting at is that addiction is a complicated subject. Someone said only opiates and nicotine are addictive, but I disagree. Someone else (Maggie?) said maybe anything that makes you feel good can be addictive- I think that's closer to the truth.
It might have more to do with the addict than the substance. I suspect that for some addicts, if the substance they're addicted to didn't exist they'd be addicted to something else.
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I agree it depends on the person. I have tried basically everything besides PCP, Meth, and Crack. Although I think if you've tried coke you've basically tried a milder version of crack. I had the philosophy of trying everything once to see what it was like. I even Slammed heroine and really you have no idea what ecstasy is unless you've experienced heroine via IV. MDMA doesn't even come close. I may have exceeded the one time limit, but never by more than one more additional "trial". The only thing that has been successful at getting me addicted is Nicotine. The only things I would recommend to other people would be pot and Mushrooms.
 
hah ok I O.D.'d On Life Itself in the 70's
hah yeah smack IS whack! I never got those folks that got a taste of a lil sumthin' sumthin' and became lost in it
coke meth horse, speedball jebus No we never had enough money (or time) to get into real trouble
we had to conserve amd 'maintain dude ;)
hah how 'bout this one, what did you (or will you) tell your kids about yer drug use?
when my kid was like 14 and asked I said: I dun it all Son and I can tell ya

'Drugs n alcohol, nothing good comes of it'
I had to wait eight years to hear "you were right about that one Dad' ;)

I've always cherished those moments ;)
 
Not sure why there's a poll on this. It's a medical fact that LSD and hallucinogenic fungi are not physically addictive. People can develop psychological addictions to these drugs, but the probability of that is lower than other recreational drugs, such as marijuana.
 
AngryOldGuy said:
hah ok I O.D.'d On Life Itself in the 70's
hah yeah smack IS whack! I never got those folks that got a taste of a lil sumthin' sumthin' and became lost in it
coke meth horse, speedball jebus No we never had enough money (or time) to get into real trouble
we had to conserve amd 'maintain dude ;)
hah how 'bout this one, what did you (or will you) tell your kids about yer drug use?
when my kid was like 14 and asked I said: I dun it all Son and I can tell ya

'Drugs n alcohol, nothing good comes of it'
I had to wait eight years to hear "you were right about that one Dad' ;)

I've always cherished those moments ;)
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I would tell them the only thing they should try is pot, if it's legal. And that's only when they're adults. I think it will be when my kid(s) (if I have any) come of age. ;)
 
Surtr said:
Not sure why there's a poll on this. It's a medical fact that LSD and hallucinogenic fungi are not physically addictive. People can develop psychological addictions to these drugs, but the probability of that is lower than other recreational drugs, such as marijuana.
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I was hoping a drug warrior would stumble in here, and try telling everyone LSD/Psilocybin are physically addictive. :cool:
 
Surtr said:
Not sure why there's a poll on this. It's a medical fact that LSD and hallucinogenic fungi are not physically addictive. People can develop psychological addictions to these drugs, but the probability of that is lower than other recreational drugs, such as marijuana.
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Such a poll gives us a good measure for how well the facts are accepted. As of now, 15% of DP pollers on this thread still think they're addictive, and another 10% don't know. 1/4 of our poll takers don't know what we think they know. We still have work to do.
 
Neomalthusian said:
I said I wasn't sure. I am guessing they are not inherently addictive, but I also assume that some people who are Polysubstance Dependent would use them habitually if available, though that probably speaks more to the person's indiscriminate substance addiction tendencies than the psychoactivity of the substances themselves.
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Psychedelics have built in abuse limiters. Tolerance increases geometrically.

It just isn't practical to trip every day.

Tolerance is short lived though. Once a week works pretty indefinitely
 
sbrettt said:
When you're young you're dumb. ;)
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and indeed quite imortal
Guess the funny thing is now that I'm well past the halfway point
and have only an ever steepening decline to look forward too
I actually have far less to lose
 
Are LSD and Psilocybin addictive?
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I don't think LSD is addictive but I know from experience that
LSD tolerance develops very quickly compared to other drugs. The dosage needed to trip out on successive days seems to increase almost logarithmically. If you drop a hit of cid one day it will take 2 or 3 hits to get the same effects the next day. And if you wanna trip the day after that too it's going to take 5-10 hits and so on and so forth. However, your tolerance goes back to normal after you abstain for 3-4 days.

And shrooms have a very similar tolerance curve. So if you want to trip on shrooms several days in a row you're going to be eating a lot of mushrooms. And they taste nasty.
 
Muhammed said:
The dosage needed to trip out on successive days seems to increase almost logarithmically.
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you are confusing Acid with LSD, we'd all wave goombye to you as you flew off with Art Linkletter's daughter Diane if you actually ever scarfed up 5-10 hits of four way window pane
 
Muhammed said:
I don't think LSD is addictive but I know from experience that
LSD tolerance develops very quickly compared to other drugs. The dosage needed to trip out on successive days seems to increase almost logarithmically. If you drop a hit of cid one day it will take 2 or 3 hits to get the same effects the next day. And if you wanna trip the day after that too it's going to take 5-10 hits and so on and so forth. However, your tolerance goes back to normal after you abstain for 3-4 days.

And shrooms have a very similar tolerance curve. So if you want to trip on shrooms several days in a row you're going to be eating a lot of mushrooms. And they taste nasty.
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Then there's the cross tolerance.
 
AngryOldGuy said:
you are confusing Acid with LSD, we'd all wave goombye to you as you flew off with Art Linkletter's daughter Diane if you actually ever scarfed up 5-10 hits of four way window pane
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LSD and acid are the same thing. "Acid" is the street name for lysergic acid diethylamide in my neck of the woods. And 4-way simply means 4 doses.
 
um no the 'acid' that you were taking IS not LSD, two completely different things!
trust me if you'd dropped 5 to10 hits of four way (20 to 40 hits! when one was like whoah dude)
you'd have gone so far away you'd have never found you way back!

I used take the dropper bottle and squirt it in my mouth between soakin' sugarcubes n or blotter paper back in them thar mid-70's highschool daze
I must agree 'acid' became quite a bore really fast. Teenage Wasteland there're all WASTED Then Nancy said NO! We cut off our shoulder length hair, disco died, we got the new Coke and started listening to Ant Music

Personally IRAN towards that shining city on a hill
 
course there who'd never grown their hair out to start with and were stuck in the The Space age
 
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