View Poll Results: Are LSD and Psilocybin addictive?

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    5 11.90%
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    32 76.19%
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Thread: Are LSD and Psilocybin addictive?

  1. #21
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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by Hard Truth View Post
    From both my reading and personal experiences, most people do not desire to use those drugs on a regular basis, even after using them several times, so they are not addictive. I did know on guy who used LSD everyday for a few months, but he had existing mental issues and seemed to be wanting to avoid doing anything with his life.

    There is a theory that people who use XTC and other psychedelics often for a long time tend to get into speed abuse later on, because they no longer get the same effect from the psychedelics. (they don't get the same effects from the speed as they did with XTC, but it does provide a consistent high)
    Actually, where I come from XTC's are a street name for fake Ecstasy. I'm thinking you were referring to real Ecstasy. I don't think it's accurate to lump MDMA with Psilocybin/LSD when talking about addiction. Yes, they both have hallucinogenic properties, but LSD and Psilocybin do not interact with the reward center. MDMA on the other hand, heavily interacts with the reward center.
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  2. #22
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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by sbrettt View Post
    Well Sex activates the reward center in the brain. That is inherently what addiction is. Pretty much anything that binds to, or promotes the release of dopamine is addictive. Psilocybin and LSD do not have an effect on the reward center and they do not interact with dopamine.
    LSD is a partial agonist towards dopamine (and seratonin) receptors in the brain. So while it may not contribute to a release of dopamine itself, it does bind to the same receptors, and "mimics" dopamines role in the brain to some degree.

    I would not classify LSD (or psilicobyn) as an addictive substance, but for some usage does bring pleasure, and pleasure itself is a result of activation of the reward centers of the brain.

    My comment still stands, pleasure itself (if anything) is the addictive thing here, and to some (including myself many, many times in my past) a good hard trip is extremely pleasurable. For others it might be ice cream, or sex, or skydiving.. regardless all of these examples do activate the rewards system of the brain, which is why they are pleasurable to begin with.
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  3. #23
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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by marduc View Post
    LSD is a partial agonist towards dopamine receptors in the brain. So while it may not contribute to a release of dopamine itself, it does bind to the same receptors, and "mimics" dopamines role in the brain to some degree.

    I would not classify LSD (or psilicobyn) as an addictive substance, but for some usage does bring pleasure, and pleasure itself is a result of activation of the reward centers of the brain.

    My comment still stands, pleasure itself (if anything) is the addictive thing here, and to some (including myself many, many times in my past) a good hard trip is extremely pleasurable. For others it might be ice cream, or sex, or skydiving.. regardless all of these examples do activate the rewards system of the brain, which is why they are pleasurable to begin with.
    Oh okay, you're talking an indirect activation?
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  4. #24
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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by MaggieD View Post
    I'd say anything that gives someone pleasure can become psychologically addictive. Don't know whether anyone would agree with me or not, but . . . there it is.
    Sure, in the same way donuts can be addictive.
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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by sbrettt View Post
    Sure, in the same way donuts can be addictive.
    Oh, God, Brett. Your avatar's going to drive me batty!!! Ha!

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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by MaggieD View Post
    Oh, God, Brett. Your avatar's going to drive me batty!!! Ha!
    Is it a little trippy?
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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by sbrettt View Post
    Oh okay, you're talking an indirect activation?
    the activation itself is direct.

    Together, these results are consistent with a direct interaction between LSD and a portion of dopamine D2/3 receptors in pig brain, possibly contributing to the psychopharmacology of LSD.
    Interaction between LSD and dopamine D2/3 binding si... [Synapse. 2005] - PubMed - NCBI

    These results suggest that LSD not only interacts with dopaminergic receptors but also has a unique capacity for modulating dopaminergic transmission.
    Lysergic acid diethylamide (LSD) is a partial agoni... [Life Sci. 1998] - PubMed - NCBI

    I am not an expert on addiction here, but that is just the first couple of hits from a quick google scholar search. I think that once the drug wears off it is no longer bound to the seratonin receptors so they again function normally, and any releases of seratonin while under the influence are not a drastic departure from normal to begin with.
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  8. #28
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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by marduc View Post
    the activation itself is direct.



    Interaction between LSD and dopamine D2/3 binding si... [Synapse. 2005] - PubMed - NCBI



    Lysergic acid diethylamide (LSD) is a partial agoni... [Life Sci. 1998] - PubMed - NCBI

    I am not an expert on addiction here, but that is just the first couple of hits from a quick google scholar search. I think that once the drug wears off it is no longer bound to the seratonin receptors so they again function normally, and any releases of seratonin while under the influence are not a drastic departure from normal to begin with.
    LOL with my lack of knowledge those links might as well look like this; "fjkbvjkrtbgukbtrkgvktrgbvtyrb". Although it sounds like it doesn't bind to dopamine like cocaine, but it promotes the release of it? Is this only for LSD, or does it also apply to Psilocybin?
    Quote Originally Posted by Peter Grimm View Post
    Should I be free to buy anthrax and a rocket launcher?
    Quote Originally Posted by Phil_Osophy View Post
    Is there a reason you shouldnt be free to?
    Quote Originally Posted by Tothian View Post
    Obamacare wants to put a chip inside people. There is a video of it on youtube.

  9. #29
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    Re: Are LSD and Psilocybin addictive?

    Here is a great link I just stumbled on..grab the LSD mouse and plop him in the chair and enjoy

    Mouse party!
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  10. #30
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    Re: Are LSD and Psilocybin addictive?

    Quote Originally Posted by Hard Truth View Post
    From both my reading and personal experiences, most people do not desire to use those drugs on a regular basis, even after using them several times, so they are not addictive. I did know on guy who used LSD everyday for a few months, but he had existing mental issues and seemed to be wanting to avoid doing anything with his life.

    There is a theory that people who use XTC and other psychedelics often for a long time tend to get into speed abuse later on, because they no longer get the same effect from the psychedelics. (they don't get the same effects from the speed as they did with XTC, but it does provide a consistent high)
    I've been known to get some pretty incredible highs from xtc.

    This one gives me eargasms every time:

    "you're better off on Stormfront discussing how evil brown men are taking innocent white flowers." Infinite Chaos

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