So God created man in his own image, in the image of God he created him; male and female he created them. Genesis 1:27
... is a biggie in my humble opinion. Unless you try to take the apologetic view that evolution was guided by a god, the process of natural selection leading to evolution of species dispels the idea that man was created in God's image. There's too thorough of an explanation for the evolution of homo sapiens and too many extinct, but still fully sentient hominid species -- homo erectus, homo neanderthalensis, etc. -- for that idea to be plausible. Even non-extinct species like today's chimpanzees and orangutangs being able to show that they are capable of having an idea of self and displaying rudimentary consciousness is troublesome to the idea that we are the only ones created, instead of having inherited those traits from a common ancestor.
Also gets me, as I have posted before, that there's still the idea that 'male and female' were created, and were created for each other. Knowing several intersex-by-birth (~1% of live human births have noticeable degrees of androgyny) and also transgendered people, and more importantly, a somewhat lukewarm understanding of the mechanisms behind those conditions, turns that 'male and female' statement into very over-simplified version of what actually goes down in nature.
