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Canadian vaccine for Ebola virus proves highly effective in Guinea trial - The Globe and Mail
Great news.
Great news.
The clinical trial, which began in March, 2015, marks the first time any vaccine for Ebola has passed the hurdles required for regulatory approval. Other trials that began around the same time foundered because infection rates in Western Africa were dropping too rapidly by then to provide a statistically significant result.
To overcome the dearth of new cases, the WHO team adopted a “ring vaccination” strategy. The approach was originally devised to help shut down the last remaining clusters of smallpox, leading up to its eradication in 1980. During the WHO trial, only those individuals who were close contacts of a new Ebola case, including family members and neighbours, as well as contacts of those contacts, were vaccinated. Whereas members of a randomly chosen West African cohort might only have a minute chance of contracting Ebola , those in the ring of contacts around a new case would be at much higher risk. This translates into a higher confidence level in results of the trial.
“It was a brilliant study design, given the circumstances,” said Frank Plummer, a professor at the University of Manitoba and former scientific director general of the National Microbiology Laboratory in Winnipeg.