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U.S. court rules against Obama's stem cell policy

It seems that you create logic boxes that demand I accept your pre-conceived conclusion or admit I'm an uneducated hypocritical dolt.

I realize the source of the eggs, the source of the cells. The issue isn't the source, but the moral and ethical grounding for taking what would be an otherwise viable human and using it for research.

If the Embryonic Stem Cell research is as potentially productive as the claims would have it, then private funding can have it. Federal Funds should not have anything to do with it.

This has long been my primary objection to federal funding of stem cell research. If this is truly viable as a medical procedure more than a science lab theoretical pipe dream, then wouldn't medical companies be fully funding it? To my knowledge there has NEVER...not EVER been a ban on funding of stem cell research of any type. the ONLY 'ban' has been on FEDERAL funding of embryonic stem cell research.
 
That's all that really matter to you? How Obama looks.

You couldn't care less about Stem Cell research or the real issue, but as long as it can be used against Obama...

Nothing to see here folks, move along.

Let's see are the marvels as a result of EMBRYONIC stem cell research.
 
This has long been my primary objection to federal funding of stem cell research. If this is truly viable as a medical procedure more than a science lab theoretical pipe dream, then wouldn't medical companies be fully funding it? To my knowledge there has NEVER...not EVER been a ban on funding of stem cell research of any type. the ONLY 'ban' has been on FEDERAL funding of embryonic stem cell research.

No, the private sector won't necessarily fund it. If it is too risky, creates too much liability, or the profit potential is not certain enough, they will pass. Vaccines and antibiotics are probably the two most beneficial medical interventions in history, yet neither is pursued by private industry with the same vigor as more profitable (still beneficial) products, such as statin drugs for cholesterol.

This is the problem with relying on private enterprise for everything. Most of the time the profit motive roughly aligns with public interest, but not always. This is one case where it does not.
 
Embryonic stem cells are a dead-end technology. There is always potential rejection issues when you implant the tissue into the patient if you use embyonic stem cells. The wave of the future is induced pluripotent stem cells, as there are no possible rejection issues since the tissue is derived from the patient's own cells. These also avoid the moral issues raised with destroying embryos to harvest the cells.

So the federal government should not even be funding embryonic stem cell technology.
 
Wow, the adminstration is suing everything these days.

Actually, they didn't sue. They were sued, and are now appealing the lower court's decision.
 
Embryonic stem cells are a dead-end technology. There is always potential rejection issues when you implant the tissue into the patient if you use embyonic stem cells. The wave of the future is induced pluripotent stem cells, as there are no possible rejection issues since the tissue is derived from the patient's own cells. These also avoid the moral issues raised with destroying embryos to harvest the cells.

So the federal government should not even be funding embryonic stem cell technology.

what he said...
 
No, the private sector won't necessarily fund it. If it is too risky, creates too much liability, or the profit potential is not certain enough, they will pass. Vaccines and antibiotics are probably the two most beneficial medical interventions in history, yet neither is pursued by private industry with the same vigor as more profitable (still beneficial) products, such as statin drugs for cholesterol.

This is the problem with relying on private enterprise for everything. Most of the time the profit motive roughly aligns with public interest, but not always. This is one case where it does not.

Im pretty sure that was the point. If there is profit potential they would develop it. I dont know enough about it to speak on stem cell research but I DO believe this emphasis on embryonic stem cell research becomes more an issue of we can vs we should. 20-30 years from now will we be looking at trillions of dollars spent on research and sit back and go...huh...THAT was a waste of time and money...

I would actually prefer to see all the universities and labs team up...go to maybe one or two major research institutes. Better maximize resources.
 
what he said...

It's actually not too complicated. A stem cell basically can basically form any kind of tissue you want based on the cells around it. This is why they are valuable.

Embryonic stem cells come, obviously, from embryos. Embryos contain some traces of the mother, even if you remove the DNA. So this is why if you develop tissue from embryonic stem cells you are going to run into the issue of rejection.

Induced pluripotent stem cells are pretty amazing. You can take any of your cells, transfect with viruses to change the DNA to get it to become a stem cell (though better methods are being developed since transfection can lead to tumors). Rejection would be impossible with this method, and there is no moral opposition to this method.

Which is why I say that embryonic stem cells are a worthless endeavor and induced pluripotent stem cells are where the funding should go.
 
appears the court made the right decision, time to repeal this stupid law though.
 
Apples and Oranges buddy. WWII is not the same as this, Hiroshima and Nagasaki were bombed TO SAVE LIVES, or did you miss that part?
The problem, and why you hate these debates it would seem, is that you lack perspective, historical understanding or even common sense it would appear.
Your comments are NOT Consistent. So you're COOL with killing embroy's, but ending WWII in a manner that saved millions was evil. You have no moral compass sir.

And stem cell reasearch isn't done to save lives? Of course it is.
And no, I'm not cool with "killing embroy's" or as I assume you mean, killing embryos. Who is? This debate has nothing do with killing embryos. It has to do with using embryos that are going to be discarded for stem cell research. As most of your arguments are, that one was a straw man.

We killed a quarter of a million people when we bombed Hiroshima and Nagasaki, and thousands more died each year after that. They were mostly innocent civilians.

The bottom line is that I wasn't comparing Hiroshima to stem cell research. They're not comparable in the least. I was pointing out that the opponents of stem cell research often claim to be inspired by their regard for how precious life is, but couldn't care less about the lives of innocent people elsewhere. And since you appear to be unsymptathetic to the hundreds of thousands of innocent lives lost in Japan, it would appear that my argument is entirely valid.
 
I've always been curious about these types of responses. Do you feel this way because you think the embryos are forcibly removed from a woman for research purposes, or do you realize that the embryos destroyed were headed into the dumpster anyway? If you realize that the latter is the truth, are you equally opposed to fertilization procedures that millions of Americans will attempt in order to make a baby this year alone?

If we use the logic that they were headed for the dumpster bin, then what stops us from using each other as guinea pigs? Since we are all headed for the same dumpster bin eventually.

It seems that the only way one can be opposed to embryonic stem cell research is to simultaneously oppose IVF, which pretty much kills the "I have more regard for human life than you do" argument. I'm not making fun of your argument by any means, but I am understandably curious.

Embryonic stem cell research kills life. It is completely different then any other type of medical research out there.

Also, can you be for IVF, then complain about overpopulation? That one has always perplexed me.
 
Ahhh. Well, the way I look at it is that most of those embryos were on the way into the biohazard flames as they were approaching unviability.

Who gets to determine which ones are viable and which aren't though? And how does somebody know a life is about to approach (un)viability?

These are the kinds of moral and ethical questions that should be considered when dealing with life in general.

I think there is a tendency to lump an embryo in with a baby among a lot of folks, and probably assume that these embryos were on their way to becoming an actually baby before the process of stem cell research interrupted all that.

The embryo is a baby. The 2 are not seperable.

To be honest, I just do the research, and I don't dwell on the potentiality of it all. I know it's a big deal among many folks, but i'd be curious to see if that would change if many folks realize that it's no different than IV fertilization, when it comes right down to it.

Which also leads to other moral and ethical issues. Although, IVF and ESCR, are not the same thing either.
 
You are correct in that adult stem cell research has been very promising, but embryonic has not been a disappointment. Given the hoopla around all of it, it hasn't seen the funding that it needs up until recently. I'm certainly not qualified to compare the two, but I can talk all day about embryonic stem cell research and how fast things are moving along. Unfortunately, it looks as if it's now going to again suffer with funding issues. And just to set things straight, all embryonic stem cell research is done on 'leftovers' which are approaching nonviability - no one yanks an embryo from the mother and denies her a fetus in the name of research. I can tell you that everything that we got was a step away from the biohazard trash bin. Not sure if that changes your opinion any, but there it is.

Why aren't there more private institutions taking up the mantle on ESCR? Why are you guys relying solely on government to fund this?
 
I worked many years in adult stem-cell research and can tell you that it matters not whether a stem-cell comes from and embryo or an adult, they serve the same function. Once the stem-cell is programmed with the DNA in question or grafted into the host area, it functions much the same. So to say that one is more promising than the other is not accurate. A stem-cell is a stem-cell. Now, whether or not there is the same promise in the future after newer discoveries are made is hard to say because embryonic stem-cells have been held back due to social issues thus have much more ground to make-up in order to have the same usage levels as adult stem-cells.

If there is no difference, why are we doing both? Why not just do one of them and throw the other to the wolves?

Otherwise, if the government is funding both, doesn't that mean they are funding the same program twice? aka....double dipping.
 
That's all that really matter to you? How Obama looks.

You couldn't care less about Stem Cell research or the real issue, but as long as it can be used against Obama...

My heart sank when I read that, because stem cell research is so very important ...
 
TheHat;

First off, these are very good questions that you are asking. I believe that you (and others opposed) to embryonic research have a right to have your concerns addressed - something that far too many people on my side of the fence don't spend enough time doing, imho. If we can have a more open, honest exchange, we can work together to dispell a lot of the myths out there about what goes on in this type of research, and at least both sides can be more informed about the other, even if we still end up in disagreement. So i'll certainly address your issues.

If we use the logic that they were headed for the dumpster bin, then what stops us from using each other as guinea pigs? Since we are all headed for the same dumpster bin eventually.

I have two parts to this answer. For one, we are dealing with embryos - specifically, embryos which are pretty much unviable. What this means is that, were we to actually attempt to grow these embryos in an attempt to make a "test tube baby", they simply would not take. I can tell you that many which have come our way were physically very damaged from whatever happened during their term of storage in their respective clinics. For purposes of baby-making, these just won't work. For research purposes, however, they will. So, these embryos are different from the ones which we would call 'viable' - those which could still be used in IVF. Given that the concern is over a viable fetus which could potentially become a baby, we are now capable of differentiating between the type of embryo used in research, and the viable version, which is where the concern lies if I am reading the opposition correctly.

For another, we do "use each other as guinea pigs" when it comes to research, do we not? How many times have you heard about terminal cancer patients with little hope and, as a result, end up volunteering for experimental medications? For that matter, what about the "safer" experiments offered by many universities looking for voluntary participants, many of which offer cash? I'd say it's pretty fair to say that yes, we do research on our fellow human beings - even untested, potentially dangerous research, depending on how life-threatening the condition.

Embryonic stem cell research kills life. It is completely different then any other type of medical research out there.

I'd say this is definitely false, and I think you'd agree. Almost all research inevitably needs a test subject(s), and one of the more popular is, of course, bacteria. How many colonies have been eradicated from simply searching for new antibiotics? But let's move a bit higher up the chain. What about lab mice? I can't tell you how many i've seen killed at various parts of my career, and I was just one of a team of researchers in a small lab. And such experiments aren't limited to those organisms; there are a number of different species involved in medical research, and while it may eventually lead to good news for human beings, from the standpoint of the organism involved, medical research is bad news.

But what about the embryo? Well, I think the entire question boils down to this: given that there is no chance of that embryo eventually becoming a walking, talking, undamaged human being if we were to do our best to make it such, would you still oppose embryonic stem cell research, or does that alter the conditions enough for you to "ride the fence", so to speak?

Also, can you be for IVF, then complain about overpopulation? That one has always perplexed me.

Good question, but I am neither opposed to IVF or population increase. You'd have to ask someone with much stronger opinions than myself on the subject, i'm afraid.

Who gets to determine which ones are viable and which aren't though? And how does somebody know a life is about to approach (un)viability?

Another good question. I should preface this by saying that, in the abortion debate, we often hear the term 'fetal viability'. Medically speaking, this is different than embryonic viability for IVF and research, in the fact that we are not dealing with a fetus, but an embryo. Clinics that i've dealt with have staff knowledgeable about the damage suffered during cryopreservation, and we can determine this as well upon arrival. In the past, we've rejected a number of samples simply because they were too damaged for any purpose. But we've never recieved any sample that was in excellent condition after cryopreservation. Those samples will never see the inside of a research laboratory, as they are still quite viable.

The embryo is a baby. The 2 are not seperable.

At the risk of saying something offensive to you or any person on the pro-life side of the abortion debate, let me preface by saying I totally understand and respect your view about life and the soul inhabiting the body at conception. I am answering this position from a scientific point of view, and from my own first-hand knowledge of the matter. In no way, shape, or form am I disagreeing with any ethical questions you have answered on the subject; i'm simply giving a scientific, morally-neutral answer.

Scientifically speaking, an embryo is not a baby, as 'baby' is typically used as a postnatal term in fetal medicine. An embryo is the first stage in in human development, after which it becomes a fetus (typically 8 weeks). Tissue development and organogenesis are two of the main characteristics of this stage, along with early limb development, and - if all is well - no chromosomal abnormalities.

I hope I was able to answer all of your concerns. If there are any others, feel free to post them. I think we have a nice discussion going, and for that, I thank you. Thanks, TheHat!
 
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I hope I was able to answer all of your concerns. If there are any others, feel free to post them. I think we have a nice discussion going, and for that, I thank you. Thanks, TheHat!

Singularity - you are the most reasonable and well informed poster that I have ever seen during my short time - less than 2 years - browsing these boards.

Its nice to see someone who actually knows what they are talking about, posting apparently well thought out positions, backed up by facts.
 
Singularity, there is no reason to support embryonic stem cell research with the advent of the Yamanaka Method for creating induced pluripotent stem cells. Never mind the fact that using embryos to develop stem cells capable of producing tissues has never worked, the Yamanaka Method avoids the moral dilemma and is much more effective.
 
Singularity, there is no reason to support embryonic stem cell research with the advent of the Yamanaka Method for creating induced pluripotent stem cells. Never mind the fact that using embryos to develop stem cells capable of producing tissues has never worked, the Yamanaka Method avoids the moral dilemma and is much more effective.

While I agree that inducing somatic stem cells avoids the controversy, I am not very familiar with the specifics of how much success this has met on a large scale. I do know that the genes for pluripotency have been isolated, but as I mentioned previously, our laboratory does not work with any somatic lines, so my only familiarity with it is through work relationships with laboratories that do. That being said, I can tell you what advantages the embryonic model has over the somatic counterpart (see earlier post in this thread, a few pages back). Also, to be fair, embryonic stem cells have not had the luxury of federal funding that somatic experienced, so we can expect greater advances from somatic stem cells for that very reason.

However, let me clear up one thing in your post that is false, which is that induced somatic stem cells are "much more effective". In some things, yes. In others, no. I can give you a personal example here where embryonic is more effective. A few months ago we were partnered with a laboratory out of Kentucky for a project. This particular laboratory was set up for somatic stem cell research, and both of us were working towards the same goal. From the get-go, growth problems and outright culture failure plagued them, which is typical when dealing with somatic lines. From what I understand, the expense report for the entire shebang was pretty costly from their end - not just for new cells, but for maintenance, equipment, etc. So you're looking at greater expense, which means larger funding is probably going to be required. Currently, they are still plugging away at their end of the project. We finished ours a while ago. Turnaround time and speed of research are definite advantages to embryonic stem cell research.

However, I need to reiterate that embryonic stem cell research is NOT "better" than its somatic stem cell counterpart, or vice-versa. Both have their advantages and disadvantages, which I covered in this thread. The main concern seems to be the ethical questions about embryonic stem cell research, not the science.
 
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While I agree that inducing somatic stem cells avoids the controversy, I am not very familiar with the specifics of how much success this has met on a large scale. I do know that the genes for pluripotency have been isolated, but as I mentioned previously, our laboratory does not work with any somatic lines, so my only familiarity with it is through work relationships with laboratories that do. That being said, I can tell you what advantages the embryonic model has over the somatic counterpart (see earlier post in this thread, a few pages back). Also, to be fair, embryonic stem cells have not had the luxury of federal funding that somatic experienced, so we can expect greater advances from somatic stem cells for that very reason.

ES cells have not been successful Adult vs. embryonic stem cell success now quoted at 70 to 0 | Geneforum, whereas iPS cells have been used in mice and other organisms, though the transfection method currently used to produce them results in tumor formation. Some kind of transposon system will have to be used in conjuction with a DNA binding protein in order to decrease the likelihood of these tumors.

[/quote]However, let me clear up one thing in your post that is false, which is that induced somatic stem cells are "much more effective". In some things, yes. In others, no. I can give you a personal example here where embryonic is more effective. A few months ago we were partnered with a laboratory out of Kentucky for a project. This particular laboratory was set up for somatic stem cell research, and both of us were working towards the same goal. From the get-go, growth problems and outright culture failure plagued them, which is typical when dealing with somatic lines. From what I understand, the expense report for the entire shebang was pretty costly from their end - not just for new cells, but for maintenance, equipment, etc. So you're looking at greater expense, which means larger funding is probably going to be required. Currently, they are still plugging away at their end of the project. We finished ours a while ago. Turnaround time and speed of research are definite advantages to embryonic stem cell research.[/quote]

It doesn't matter if your work was faster because even if you are fully successful with ES cells you cannot avoid the fact that you still possibly face rejection issues. This is not possible with iPS cells.

However, I need to reiterate that embryonic stem cell research is NOT "better" than its somatic stem cell counterpart, or vice-versa. Both have their advantages and disadvantages, which I covered in this thread. The main concern seems to be the ethical questions about embryonic stem cell research, not the science.

The only disadvantage with iPS cells is the transfection method to produce them which is costly and can lead to tumors. However, newer methods are being developed which are efficient and will not lead to tumors.
 
Phattonez;

Before we continue forward, we need to clear up any further misconceptions about the research. We both can certainly agree that embryonic stem cells carry a lot of ethical questions, but let's put that aside for the moment and focus on the science. There are a few things in your latest post that we should address, then we can proceed further.

iPS cells have been used in mice and other organisms, though the transfection method currently used to produce them results in tumor formation

There are a few points within this quote that we should clear up.

1. First, you mention the "transfection method currently used to produce [the stem cell]". It's important to note that there is not one particular transfection method used in this research, but several, and currently there is no smoking gun pointing definitively towards any transfection method being the root cause of tumor formation. In every transplantation, you have a small amount of contamination by non-mature cells, which can lead to tumors. Researchers at Lund University have done studies on how to prevent tumor formation in stem transplants, and published their results this summer in Proceedings of the National Academy of Sciences, should you wish to have a look at the article. There is also a number of theories floating around about other root causes, including a study two years ago which observed a link between cells with highly active mitochondria and tumor formation Mitochondrial Metabolism Modulates Differentiation and Teratoma Formation Capacity in Mouse Embryonic Stem Cells.

2. Tumor formation by stem cells is not limited to somatic, but includes embryonic stem cells as well. Like any other cells, stem cells undergo genetic damage leading to mutations. Because stem cells are so long lived, the potential for accumulation of much smaller damage over a longer period to the genome can act as a seed to tumor formation and cancer growth. Given that embryonic stem cells multiply very rapidly, the potential to form teratomas is high. While this is a drawback to transplantation, consider the possibilities to cancer research, which is what our particular lab is involved in. Over the summer, researchers at UC San Diego working with embryonic stem cells have discovered how to inhibit embryonic cells from forming teratomas, a finding which could presumably lead to new treatments down the road. You can read the article in July's Proceedings of the National Academy of Sciences, or read a summation here: Biology News - UC San Diego Biologists Find Way to Lower Tumor Risk in Stem Cell Therapies

The only disadvantage with iPS cells is...

There are a few advantages to using either somatic stem cells or embryonic stem cells that I posted a few pages back. There are more, but in the interest of not stretching that particular post out, I compacted them to three advantages each.

It doesn't matter if your work was faster because even if you are fully successful with ES cells you cannot avoid the fact that you still possibly face rejection issues. This is not possible with iPS cells.

Believe it or not, I get this quite often. For some reason, people assume that stem cell research is limited to organ transplants and regenerative therapies, when in fact this is just one branch of the research. For instance, our lab is doing research with cancer stem cells. Other labs are doing research with using embryonic stem cells to cure other diseases as well. The research is so exciting because of this. There are numerous scientific articles you can read online or at the library regarding the various avenues this research is travelling, should you wish to read more.

ES cells have not been successful Adult vs. embryonic stem cell success now quoted at 70 to 0 | Geneforum

I couldn't help but notice a glaring omission by Ms. Godfrey when she wrote the following line: "Embryonic stem cells, on the other hand, have yet to prove themselves." While she does go on to acknowledge that the limitations are a factor, nowhere in her blog did I see any mention of the recent advances in embryonic stem cell research, nor of the recent drawbacks to limiting ourselves to induced somatic stem cell research. I wonder what Ms. Godfrey would say about these? Whitehead Institute - Embryonic stem cells reveal oncogene’s secret growth formula ; Epigenetic memory in induced pluripotent stem cell... [Nature. 2010] - PubMed result ; Cell type of origin influences the molecular and f... [Nat Biotechnol. 2010] - PubMed result ; Induced Pluripotent Stem Cells Do Not Fully Replace Embryonic Stem Cells As Disease Models, EU-funded Study Shows

As a general rule, I would avoid blogs as any sort of scientific fact because more often than not, they reflect opinion rather than actual science. While I am sure Ms. Godfrey is amply qualified, my first question to her would be what, if any, research has she done with embryonic stem cells? If none, what - if any - embryonic stem cell research is she familiar with? I don't recall anyone by her name ever calling and talking to me about our research, and I see little on her blog indicating that she has ever delved into anyone else's either. I run into that quite often as well. There are many colleagues of mine who do not work with this particular research, but who have rather strong opinions on the matter. It has nothing to do with their qualifications, and everything to do with their ethical opinion. And that's where the debate lies - not in the science, but the logical inquiry into the morality of it all.

Thanks.
 
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