1) Are the radicals and extremists wrong?
After all, when the pagan establishment of Mecca began to confiscate Muslim homes and property it was Muhammed that authorized the uprisings. It was Muhammed that led ambush parties against Meccan caravans to achieve an economical base. And it was Muhammed that eventually led a Muslim army back to Mecca where the pagan establishment fell with little fight. Today, Muslim radicals and extremists are convinced that westernization is a direct assault upon Islam (and Muslims) and that militant organizations to defend it are justified.
2) Do Muslims in the region mean it when they condemn terrorist activity?
If they do, then where are the Muslim armies combatting those who pervert and destroy Islam's image to the world? It makes no sense that Muslims throughout the region can unite, riot, and protest the west whenever they are all lumped into stereotypes as if Islam just suffered the worst insult, but find no will to unite against those who truly destroy their religion directly in their midst.
The fact is that even Muslims in the region are confused about the true identity of their religion. Christians who kill in the name of God can't get away with "what would Jesus do." But can Muslims who are looking back for guidance in describing their religion? Reform is that much harder for the faithful when the inventor of their religion set the example.