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Thread: Man appears free of HIV after stem cell transplant

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    Man appears free of HIV after stem cell transplant

    Source [CNN | Man appears free of HIV after stem cell transplant]

    A 42-year-old HIV patient with leukemia appears to have no detectable HIV in his blood and no symptoms after a stem cell transplant from a donor carrying a gene mutation that confers natural resistance to the virus that causes AIDS, according to a report published Wednesday in the New England Journal of Medicine.

    [...]

    "The patient is fine," said Dr. Gero Hutter of Charite Universitatsmedizin Berlin in Germany. "Today, two years after his transplantation, he is still without any signs of HIV disease and without antiretroviral medication."

    The case was first reported in November, and the new report is the first official publication of the case in a medical journal. Hutter and a team of medical professionals performed the stem cell transplant on the patient, an American living in Germany, to treat the man's leukemia, not the HIV itself.

    However, the team deliberately chose a compatible donor who has a naturally occurring gene mutation that confers resistance to HIV. The mutation cripples a receptor known as CCR5, which is normally found on the surface of T cells, the type of immune system cells attacked by HIV.

    [...]

    While promising, the treatment is unlikely to help the vast majority of people infected with HIV, said Dr. Jay Levy, a professor at the University of California San Francisco, who wrote an editorial accompanying the study. A stem cell transplant is too extreme and too dangerous to be used as a routine treatment, he said.

    "About a third of the people die [during such transplants], so it's just too much of a risk," Levy said. To perform a stem cell transplant, doctors intentionally destroy a patient's immune system, leaving the patient vulnerable to infection, and then reintroduce a donor's stem cells (which are from either bone marrow or blood) in an effort to establish a new, healthy immune system.

    Levy also said it's unlikely that the transplant truly cured the patient in this study. HIV can infect many other types of cells and may be hiding out in the patient's body to resurface at a later time, he said.

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    Re: Man appears free of HIV after stem cell transplant

    Hmmmmm. Sounds promising.
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    Re: Man appears free of HIV after stem cell transplant

    Quote Originally Posted by Goldenboy219 View Post
    Hmmmmm. Sounds promising.
    The FDA just gave approval to test a stem cell therapy for spinal injuries as well

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    Re: Man appears free of HIV after stem cell transplant

    Wow, this is excellent. The potential is there.

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    Re: Man appears free of HIV after stem cell transplant

    That's fantastic news.

    I'm glad that people started to wisen to this
    "I do not underestimate the ability of fanatical groups of terrorists to kill and destroy, but they do not threaten the life of the nation. Whether we would survive Hitler hung in the balance, but there is no doubt that we shall survive al-Qa'ida." -- Lord Hoffmann

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    Re: Man appears free of HIV after stem cell transplant

    While promising, the treatment is unlikely to help the vast majority of people infected with HIV, said Dr. Jay Levy, a professor at the University of California San Francisco, who wrote an editorial accompanying the study. A stem cell transplant is too extreme and too dangerous to be used as a routine treatment, he said.

    "About a third of the people die [during such transplants], so it's just too much of a risk," Levy said. To perform a stem cell transplant, doctors intentionally destroy a patient's immune system, leaving the patient vulnerable to infection, and then reintroduce a donor's stem cells (which are from either bone marrow or blood) in an effort to establish a new, healthy immune system.

    Levy also said it's unlikely that the transplant truly cured the patient in this study. HIV can infect many other types of cells and may be hiding out in the patient's body to resurface at a later time, he said.
    Looks like several people failed to read everything. What potential, what everyone cheering about?
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    Re: Man appears free of HIV after stem cell transplant

    Quote Originally Posted by Arch Enemy View Post
    That's fantastic news.

    I'm glad that people started to wisen to this
    Wising up to what?
    "He who does not think himself worth saving from poverty and ignorance by his own efforts, will hardly be thought worth the efforts of anybody else." -- Frederick Douglass, Self-Made Men (1872)
    "Fly-over" country voted, and The Donald is now POTUS.

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    Re: Man appears free of HIV after stem cell transplant

    Quote Originally Posted by American View Post
    Looks like several people failed to read everything. What potential, what everyone cheering about?
    You're missing the point.

    Apparently, transplanting stem cells is risky business. However even there is promising results from the transplanting of stem cells, then there is only the matter of tweaking it around.
    I remember reading a few years ago an article that talked how a certain type of treatment dramatically reduced the growth rate of Cancers in HUMAN patients; the hype was really high, however nothing really came out of the treatment why? Because people expect good results to automatically transform into in-practice treatment methods that work all the time. That just is not possible. Projects even with the best of results, or the worst of results, are always built upon and built upon and built upon and built upon.
    "I do not underestimate the ability of fanatical groups of terrorists to kill and destroy, but they do not threaten the life of the nation. Whether we would survive Hitler hung in the balance, but there is no doubt that we shall survive al-Qa'ida." -- Lord Hoffmann

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    Re: Man appears free of HIV after stem cell transplant

    Quote Originally Posted by Arch Enemy View Post
    You're missing the point.

    Apparently, transplanting stem cells is risky business. However even there is promising results from the transplanting of stem cells, then there is only the matter of tweaking it around.
    I remember reading a few years ago an article that talked how a certain type of treatment dramatically reduced the growth rate of Cancers in HUMAN patients; the hype was really high, however nothing really came out of the treatment why? Because people expect good results to automatically transform into in-practice treatment methods that work all the time. That just is not possible. Projects even with the best of results, or the worst of results, are always built upon and built upon and built upon and built upon.
    I'm not against stem cell research, but I am against the rabid insistance by liberals that embryonic stem cell research is the best and only way to achieve cures. It's just another cover for abortion. Don't tell me it's not true, because the left extremists don't pump up the success of adult stem cell research. Nevertheless, the man plainly stated that this is extremely risky with little proven benefit. One patient doesn't prove the success of a process.
    "He who does not think himself worth saving from poverty and ignorance by his own efforts, will hardly be thought worth the efforts of anybody else." -- Frederick Douglass, Self-Made Men (1872)
    "Fly-over" country voted, and The Donald is now POTUS.

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    Re: Man appears free of HIV after stem cell transplant

    Quote Originally Posted by American View Post
    I'm not against stem cell research, but I am against the rabid insistance by liberals that embryonic stem cell research is the best and only way to achieve cures. It's just another cover for abortion. Don't tell me it's not true, because the left extremists don't pump up the success of adult stem cell research. Nevertheless, the man plainly stated that this is extremely risky with little proven benefit. One patient doesn't prove the success of a process.
    Dude, really?

    Why did you bring "liberals" and "left extremists" into this?

    You label too much.
    I am for stem cell research, and against (most) abortions. I am liberal-leaning.
    "I do not underestimate the ability of fanatical groups of terrorists to kill and destroy, but they do not threaten the life of the nation. Whether we would survive Hitler hung in the balance, but there is no doubt that we shall survive al-Qa'ida." -- Lord Hoffmann

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