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Yes, children with compromised immune systems should not be in general public school.
It depends. I cannot take traditional vaccines for example because I have to take a medication that suppresses my immune system (which sucks, but the larger issue I take the meds for sucks more and these meds make me symptom free), but not so much I have to live in a bubble, I just get sick about 2x as often as I used to and it lasts an extra day. There are different degrees of being compromised.