This may be of interest to you Chris.....Originally Posted by ChrisL
"Skene's paraurethral glands and ducts are homologous to the male prostate (2). Recent studies supporting this homology, as reviewed by Zaviačič et al. (3,4), are postmortem and detailed histological examinations of the urethras of 130 women, followed by biochemical and immunohistochemical studies that demonstrated expression of PSA and prostate-specific acid phosphatase (PSAP) in Skene's paraurethral glands and ducts. These studies unequivocally substantiate the existence of the female prostate.
The female homologue of the male prostate is of clinical significance not only as a focus for acute and chronic infection, but also as the origin of other pathologic entities, including adenocarcinoma (3,4), a cancer which shows, as does its male counterpart, localized expression of PSA and PSAP (3,4).
Thus, there is convincing evidence that prostatic tissue exists in the female, and that the term “female prostate” is both fully justified and preferable to the terminology Skene's glands and ducts. The latter incorrectly implies that some other structure of an extraprostatic nature, rather than the prostate itself, is involved. If the female prostate exhibits the immunopermissiveness observed in the male prostate (5), it may also serve as a site for viral latency and origin of infection in women with human immunodeficiency virus.
Of perhaps equal importance is the expression of PSA (6). The existence in women of the counterpart of the male prostate, shown to express PSA, may provide a note of caution in considering the molecular basis of the apparent anomalous expression of PSA in male and female nonprostatic tissues, e.g., in female breast (1). Given observations on the association of PSA detection in breast cancer with steroid hormonereceptor positive tumors, one may envision (6) the existence of a complex regulatory gene network controlling the expression of PSA in several organs. Therefore, a given tissue (depending on the state of cellular differentiation) may express previously repressed genes after neoplastic transformation. Also, and not mutually exclusive, somatic mutations may lead to specific changes in PSA genes in cancer cell clones (6)."
The Female Prostate