The progesterone prescription products that have been approved by the Food and Drug Administration (FDA) are safe for most people when used with the advice and care of a healthcare professional. However, progesterone can cause many side effects including stomach upset, changes in appetite, weight gain, fluid retention and swelling (edema), fatigue, acne, drowsiness or insomnia, allergic skin rashes, hives, fever, headache, depression, breast discomfort or enlargement, PMS-like syndrome, altered menstrual cycles, irregular bleeding, and other side effects.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Intravaginal progesterone gel is LIKELY SAFE when used as part of infertility treatment. But don’t use progesterone otherwise. It’s also best not to use progesterone if you are breast-feeding. Not enough ISP known about how it might affect a nursing infant.
Arterial disease: Don’t use progesterone if you have arterial disease.
Breast cancer: Avoid use unless you are directed to do so by your healthcare provider.
Depression: Get your healthcare provider’s advice first before using progesterone if you have major depression now or a history of major depression.
Liver disease: Progesterone might make liver disease worse. Don’t use it.
Vaginal bleeding: If you have undiagnosed vaginal bleeding, don’t use progesterone.
