1. Prospective changes in the nation's gun laws might be subject to constitutional challenge. That legal avenue would exist regardless of any laws adopted by Wyoming. Legal avenues and elections is where the battle should be fought. Soft secession is not the proper approach.
2. Wyoming is not a sovereign country. Federal law takes primacy over state law. Were Wyoming to adopt laws that interfere with federal enforcement beyond what is constitutionally permissible e.g., legal challenges are allowable, those acts would amount to crimes. The federal government would be justified in taking extraordinary measures in such circumstances. That it could take such measures has precedent e.g., as had been the case when it came to enforcement of the civil rights laws.
3. Should the federal government have to take such extraordinary measures, the political leaders and others responsible for bringing about such a situation should be held accountable to the fullest extent under the law. At the same time, the State of Wyoming should be required to fully compensate the federal government.