The issue is allowing Perry to take credit for Texas, and any positives that it may see within its business world, when he is not responsible for those positives.
Perry would be a horrible President. From the way he runs TX, it seems that his buddies and especially campaign donors get a lot of government benefits, including government contracts and jobs. There is no way that he can reduce government if his priority seems to be giving out government handouts, of one sort or another to those who back him.
The vaccine for HPV prevention for teenage girls is one good example of this. There is no real public protection involved in mandating that vaccine. I don't even really care for most vaccines for viruses that are, for the most part, non-lethal, but it is especially stupid to mandate a vaccine for an STD for teenage girls. It takes all of that personal responsibility you were talking about earlier away from people, not to mention freedom. And this was a Perry policy.
"A woman is like a teabag, you never know how strong she is until she gets in hot water." - Eleanor Roosevelt
Keep your religion out of other people's marriages.